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RNA Mechanisms of Resilience and Vulnerability in Aging and Parkinson’s Disease
… how cells handle RNA — the molecule that helps turn genes into proteins — may drive this process. Proteins linked to … fragments of RNA, called tRNA fragments (tRFs), may appear early in PD and could serve as important clues to what’s … trigger cell stress, inflammation, and toxicity. Impact on Diagnosis/Treatment of Parkinson’s disease: …
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Activity and Connectivity Drive Neuronal Vulnerability and Disease Progression in Parkinson’s Disease
… neuromelanin) with age are primarily affected, particularly early, in Parkinson's disease. Models incorporating this … extracellular spaces and infiltration of non-neuronal cells into the brain will be assessed. Impact on Diagnosis/Treatment of Parkinson’s Disease: Diagnosis of …
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Predicting Freezing of Gait in Parkinson’s Disease: An Objective Quantitative Exploration Combining Patient Perception with Multi-Dimensional Digital Gait Analysis & Multi-Domain Cognitive Testing
… of FOG by monitoring cognitive and motor skills to improve diagnosis, treatment, and management of this debilitating … curated from electronic health records (EHR) into an analyzable dataset. We will compare these with … effective clinical interventions related to FOG. Impact on Diagnosis/Treatment of Parkinson’s Disease: By combining …
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Reduction of NURR1 mRNA in Human Peripheral Blood Lymphocytes as a Biomarker of PD
… to identify biological markers that can be used in early diagnosis of the disease with the aim of introducing neuroprotective therapies as early in the course of the disease as possible. Impairment …
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COVID-19 Limited Series: Finding Positivity with Parkinson’s in a Pandemic
June 3, 2020
… of keeping a healthy mind and body after a Parkinson’s diagnosis and especially during COVID-19. Michael J. Fox … the Foundation’s newest ambassador for Parkinson’s research, about: Staying active in COVID-19 Combating … and coping with disruptions in daily life Embracing early engagement and inspiring others after a Parkinson’s …
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Guangwei Du, MD, PhD
… professor and director of the Hershey Brain Analysis Research laboratory of Penn State Hershey Medical Center. He … of novel MRI imaging biomarkers for Parkinson’s disease early diagnosis and progression. He is strongly interested in the …