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Developing Assays to Quantify Cys106 of DJ-1 in Distinct Oxidized States as a Potential Diagnostic Tool for Parkinson’s Disease
… the 3D Structure of Biologically Active Small Molecules in Complex with DJ-1 Study Rationale: Currently, there are no tools to predict whether someone is at risk of developing … the same conditions that can cause Parkinson’s; measuring how much “off” and “ on” DJ-1 is present in someone’s body …
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Pharmacological Targeting of the 5-HT1, A2A and NMDA Receptors: An Integrative Approach to Dyskinesia
… Objective/Rationale: The glutamate, serotonin and adenosine systems are interesting targets for pharmacological therapies in Parkinson´s disease. However, interventions addressed at single systems have so … in the human brain by the loss of dopamine neurons are complex and affect the function of several brain systems. In …
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Biomarker Development and IND-Enabling Toxicology Support for Novel, Small Molecules that Enhance Lysosomal Function for the Treatment of Parkinson’s Disease
… Parkinson’s disease (PD), neurons exhibit decreased ability to remove cellular trash. This dysfunction is caused by a … TRPML1, a channel that resides on the lysosome, has been shown to boost macroautophagy and increase lysosome function … We will also conduct animal safety studies on our compounds. If these studies they do not show major adverse …
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President’s Science Advisors Are on Our Page about What It Will Take to Speed Cures
September 25, 2012
… Michael J. Fox Foundation CEO Todd Sherer, PhD , joins the Presidential Council of … on Science and Technology (PCAST) in Washington, DC, today as the Council releases new recommendations to the President for speeding drug …
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Using Drosophila models of Parkinson’s disease to study the neuroprotective potential of tobacco and coffee
… Objective/Rationale: Tobacco and coffee users develop Parkinson’s disease at a … from developing PD. Project Description: We will test the hypothesis that tobacco and coffee contain … coffee extracts to prevent nerve cell death, and we will compare the protective effects of tobacco and coffee to …
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Team Fox Member James Mangini Invites You to Participate in His 1,000-Mile Marathon
March 1, 2012
… message from Team Fox member James Mangini. He is preparing to embark on a 1,000-mile run from South Carolina to New York City and is looking for volunteers to provide support along the way. Visit 1,000 Mile Marathon to learn …