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Second Parkinson’s Therapy Funded by The Michael J. Fox Foundation Receives FDA Approval and Advances to Market
May 22, 2020
… for MJFF’s unique investment strategy that “de-risks” early-stage projects for larger partners NEW YORK (May 22, 2020) — The Michael J. Fox Foundation for Parkinson’s Research (MJFF) announces a milestone in the Foundation’s … research funders; increases the flow of participants into Parkinson’s disease clinical trials with its online …
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Episode 2: Understanding Sleep Differences in Parkinson’s Disease with Dr. Amy Amara
November 7, 2023
… in this episode to discuss her career and findings from her research on sleep in Parkinson’s disease (PD). She shares … sleep behavior disorder may be important for developing early treatments before PD motor symptoms manifest. Amy is a … in our audience. These episodes offer a deeper dive into exciting new scientific research on Parkinson’s …
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PPMI Dispatch: Streamlined Data, Genetic Indicators and Cognitive Decline Predictors
December 19, 2019
… world. PPMI makes its robust dataset available to qualified researchers worldwide. As of this month, PPMI’s data has … for access to the Knowledge Portal on the AMP PD website . Early Indicators of Disease Recent data analysis from PPMI … that people with LRRK2 and GBA mutations but without a PD diagnosis (non-manifesting carriers) may show signs of …
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Potential Parkinson's Therapy Secures $23 Million for Testing from NIH after Foundation Funding
March 31, 2014
… out of a study funded by The Michael J. Fox Foundation for Parkinson's Research (MJFF) have enabled researchers to secure a $23 million grant from the National Institutes … Parkinson's progression. The trial investigating the compound isradipine will be the most advanced, current study …
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Overexpression of CSPalpha Using Viral Vectors in the Striatum of a-Syn 1-120 Transgenic Pre-clinicalModel
… Objective/Rationale: Research data have recently indicated that pathology in … line that represents a model of the early stages of PD. Project Description: Alpha-synuclein, … by alpha-synuclein accumulation providing further insights into early stages of PD and its possible treatmnent. …
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Targeting of Alpha-synuclein and SNARE Complex Dysfunction to Restore Synaptic Dopamine Release in a Model of Parkinson Disease Pathology
… the release of dopamine occurs, dysfunction of which leads to neuronal death via a “dying back” process. We aim to … a chaperon protein involved in the assembly of a protein complex called SNARE, involved in the release of … stages of PD. Project Description: Alpha-synuclein, the main protein that forms the Lewy bodies that are the …