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Using “Nanobodies” to Prevent Formation of Intracellular Alpha-synuclein Aggregates
… abnormal form of the protein alpha-synuclein appears to be responsible for the initiation and progression of Parkinson’s disease (PD). In previous studies, we found that the use of targeted … two systems cells use to degrade damaged and worn-out components. Next, we will inject different doses of the …
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Weather Emergency Tips for People with Parkinson’s
… with Parkinson’s and their families have extra details to consider in order to ensure symptom management and … in case you need to evacuate. Also, consider planning for where you’d go and stay, such as a hotel or with family, if you need to leave your home. Check the Red Cross’ recommendations for additional items you may need . If You …
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Reprogramming the Brain’s Non-neuronal Support Cells to Generate Functional Dopamine-producing Neurons
… for converting supportive, non-neuronal brain cells into functional dopamine-producing neurons leads to the complete reversal of symptoms in a pre-clinical model of Parkinson’s disease (PD). This … Fall 2021 RFP: Accelerating Early Proof-of-Concept Testing of Promising PD Therapies …
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SUPPLEMENT: Cytokine Production by Adaptive Immune Cells from Patients with Parkinson’s Disease: Response to Diverse Biological Stimuli
… This grant builds upon the research from a prior grant: Cytokine Production by Adaptive Immune Cells in Parkinson’s … and activation status by immune cells in patients with PD. Hypothesis: We hypothesize that patients with PD … subsets in their peripheral blood that spontaneously express pro-inflammatory cytokines and activation markers, …
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Developing a Method to Exclude Individuals with Insignificant Alpha-synuclein Aggregates from Trials of Therapies that Target Alpha-synuclein
… disease (PD). Although alpha-synuclein aggregation is a common cause of dementia, other proteins are also associated … sensitive tests called seeding assays which can be used to identify people with clumps of alpha-synuclein in the … assay, measurement of other proteins in the CSF or the presence of certain clinical features during life can …
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10 Tips for a Healthy Winter with Parkinson’s Disease
December 18, 2014
… plenty of fun with family and friends but some stressors, too. There are a few precautions people with Parkinson’s can … Keep a routine. Even if you’re on vacation or have family visiting, be sure to exercise , get enough sleep and take … your usual diet as much as possible, Rachel Dolhun, MD, recommends. “This is especially pertinent with regard to …