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Pathogenetic Mechanisms in Early-onset Parkinsonism Resulting from a Mutation in the Synaptojanin 1 Protein
… protein implicated in synaptic vesicle transport, in early-onset parkinsonism patients. The goal of our study is … synaptojanin 1 impact neuronal function may provide insight into other proteins whose regulation may have therapeutic … with support from the former Michael Stern Parkinson's Research Foundation, which merged with The Michael J. Fox …
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Cleaved Cerebrospinal Fluid Proteins as Early Biomarkers for Detection of Parkinson’s Disease.
… these will reveal whether the markers can be applied for early detection of Parkinson’s disease. Relevance to Diagnosis/Treatment of Parkinson’s Disease: Typically, … need exists for new, robust biomarkers that can detect the early PD stages. These biomarkers will be indispensable in …
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Seed Amplification Assay to Diagnose Early Parkinson's and Predict Dopaminergic Deficit Progression
July 8, 2021
… Parkinson's disease (PD) diagnosis relies primarily on clinical evaluation due to … patients. PD-BL samples were collected within 2 years from diagnosis and presented abnormal DaTscans, while SWEDD …
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Enhanced CNS transduction from AAV.PHP.eB infusion into the cisterna magna of older adult rats compared to AAV9
March 22, 2021
… of AAV.PHP.eB-CAG-GFP and AAV9-CAG-GFP when delivered into the cisterna magna of 6-9-month old rats. Using both …
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"We're Grateful for Those Moments of Joy": An Adult Daughter's Memoir Chronicles the Ripple Effects of Diagnosis on Family
April 5, 2016
… hope and happiness. What would you say to someone in those early days who is facing a diagnosis and wondering, Can my … his story and using it to raise awareness and accelerate research. My mom believed in what he did and loved him for … to laugh -- she had a sparkle in her eye and loved to get into mischief! Veronique: Is there a final message you want …