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Targeting the Lysosomal Pathway to Ease Mitochondrial Dysfunction in IPSC-Derived Neurons from People with Parkinson's and GBA Mutations
… have recently shown that loss of GCase activity gives rise to impaired mitochondrial function, itself associated with … of dysfunctional mitochondria. We now ask whether compounds that increase autophagy activity are able to … for studying basic disease mechanisms. We demonstrated that pre-clinical models lacking GBA have dysfunctional …
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Episode 29: Developing a Novel App to Improve Speech Intelligibility in Parkinson's Disease with Dr. Gemma Moya-Galé
December 17, 2024
… Parkinson's disease significantly impacts various aspects of communication, and this can make it challenging for people with the disease to communicate effectively, be understood by others, and … J. Fox Foundation Parkinson’s Podcast on Apple Podcasts or wherever you get your podcasts for future episodes featuring …
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Phase IB Follow-up Study to Assess a Second Boost Immunization With AFFITOPE® PD01A in Those Who Participated in the AFF008 Program
… the research from a prior grant: Phase IB Follow-up Study to Assess Boost Immunization with AFFITOPE® PD01A Promising Outcomes of Original Grant: Accumulation and/or aggregation of … for the Development of a New PD Therapy: Previous studies established the safety of PD01A …
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Searching for Signs of Mitochondrial Breakdown in People with Parkinson’s Disease with an Unknown Cause
… (PD) are caused by mutations (genetic changes) that lead to the breakdown of mitochondria, cell's energy generators. … could be invited to participate in clinical trials where approved compounds already known to improve mitochondrial health … Mitochondrial Dysfunction …
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Building Trust and Awareness to Make Research Welcoming to All
June 3, 2021
… The following story appeared in our Spring/Summer 2021 edition of The Fox … . Most Parkinson’s research to date has not fully represented all people who live with PD. To ensure that the … historical and cultural barriers that prevent some communities — especially communities of color — from …
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Cheers to Pints for Parkinson’s! From Florida to New Mexico to Minnesota and Beyond
October 22, 2020
… Pints for Parkinson's Orlando on October 21, 2023 Register Here In the spirit of Oktoberfest, … host an annual Pints for Parkinson’s fundraiser in their communities. It all started with Chris and Rose Babcock. … are Founding Sponsors from years ago. Rose : We would be nowhere without our friends and extended Team Fox family that …