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Shake, Rattle, and Stroll for Parkinson’s: Building Support and Community Locally
May 2, 2023
… in 2016. Just two years later, following their father Todd’s PD diagnosis, the Forsyth family started attending. … be a meaningful way to connect even further with the PD community, the Forsyth family officially took over the … is a lot of work, but it’s always very worth it because of how happy everyone is to be together. It’s not a fun reason …
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Reconstructing the neural circuits in Parkinson’s, using biodegradablepolymer bridges or striatal co-grafts to encourage neural outgrowth from transplantedtissue
… pathway, is lost. This pathway links the substantia nigra to the striatum. In neural tissue transplants for … nigra is placed into the striatum. The clinical outcome for this procedure has been variable, possibly because … has been suggested that the new neural tissue does not know how to behave without input from the substantia nigra and …
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Glove Shows Potential to Ease Parkinson’s Motor Symptoms
December 14, 2022
… MD, PhD, are developing a glove aimed at alleviating motor symptoms caused by Parkinson’s disease (PD). The device … generated a lot of excitement, so what do people in the PD community need to know about the glove and technology as treatment? We’ve answered a few common questions. How does the glove work? In early trials, participants wore …
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Testing PDE-1 Inhibitor in MPTP-treated Macaques
… a prior grant: Development of Novel Phosphodiesterase Inhibitors for the Symptoms & Side Effects Treatment of Parkinson's Disease Promising Outcomes of Original Grant : Our goal is to develop novel … therapy and reduce adverse dyskinesias. To this end, we tested a small-molecule inhibitor of the brain-enriched …
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Using Immune Cells to Treat Parkinson's Disease
… Study Rationale: While significant strides have been made toward therapies that can prevent, slow or stop Parkinson's … of treated models. The results could allow us to estimate how effective the treatment would be in slowing disease … new treatment strategy is potentially more efficient when compared to other approaches, such as those that use …
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Development of an Inhibitor of Tau Aggregation to Treat Parkinson’s Disease
… folding of the tau protein in the brain, which leads to cellular dysfunction and neurodegeneration. Preclinical and clinical studies have shown that inhibiting tau aggregation reduces neurotoxicity … of PD. Study Design: This project will evaluate two compounds, PSY-055 and PSY-106, for their ability to inhibit …