Targets to Therapies Annual Meeting

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Please join us on Wednesday, March 25th, 2026 from 12:30-2:30pm EST for a town hall meeting focused on collaborative validation efforts for endolysosomal targets in Parkinson's Disease as part of the T2T Initiative. We will discuss validation strategies and key gaps for each nominated target, and introduce opportunities for funding and collaboration. Please complete the form to register your interest and we will follow up with the Zoom link.

Please feel free to share this with anyone in your network who may be interested! 

A Family Care Stipend Program for the T2T network will support the retention and growth of graduate students, early-career researchers, and other neuroscience professionals by helping offset rising family care costs. By providing up to $10,000 per household, the program aims to sustain a diverse, robust scientific workforce essential to advancing research and accelerating progress toward a cure for Parkinson’s disease.

The Target Explorer web tool is an interactive platform that allows researchers and collaborators to review curated profiles of therapeutic targets identified by the T2T Initiative, including key biological data, available research tools, evidence gaps, and evolving validation plans.

Key to success of T2T is the opportunity to leverage the full expertise of our scientific community to inform our efforts related to these targets, whether as a grantee, advisor or collaborator on a target validation team.

While we have started with a shortlist of targets, we continue to gather input on additional targets from experts working on them. To contribute to future target prioritization, we invite you to nominate targets to be validated next. 

This document provides a high-level landscape analysis of commercially available research tools for targets within the T2T Initiative, covering 2025 targets (TMEM175, TRPML1, ATP13A2, NOD2, OGA) and 2026 targets under evaluation (STING1, TLR2, TREM2, GPNMB, VPS35, CTSB, BECN1, GBAP1). The analysis compiles information on antibodies, mouse models, cell lines, viral vectors, assays, and compounds from major commercial catalogs and databases.

The MJFF Research Tools Program works with the research community to understand the gaps in the research tool space, develop and distribute reagents and models to fill these gaps, and better understand the characteristics of available research tools.

As this meeting will be CDA-free, we requested that all attendees sign the T2T Code of Conduct. This document is agreed upon by all members of the T2T working groups to establish a common understanding of the exchange of information shared during T2T activities, freedom to operate on the targets, and mutual respect between members.