The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Accelerating Biological Understanding and Therapeutic Translation for PD-Biology, 2024Using A Screening Platform Based on Induced-pluripotent Stem Cells to Study Parkinson’s Disease
Study Rationale: This project represents a supplement to our MJFF project, “Shedding Light on the Dark Genome in Parkinson’s Disease (PD).” For the initial project, we developed a suite of...
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Accelerating Biological Understanding and Therapeutic Translation for PD-Biology, 2024Targeting Lipid Biology in Stem Cell-derived Neurons to Develop a New Therapeutic Drug for Parkinson’s Disease
Study Rationale: Neurons derived from the stem cells of people with Parkinson’s disease (PD) offer an excellent vehicle for identifying potentially disease-modifying therapeutic compounds. We...
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Measuring Alpha-Synuclein in Extracellular Vesicles, 2024Measuring Alpha-synuclein in Extracellular Vesicles: A Biomarker for the Diagnosis and Staging of Neuronal α-Synuclein Diseases
Study Rationale: Parkinson's disease (PD) and dementia with Lewy bodies involve accumulation of alpha-synuclein in neurons. A recently developed test for alpha-synuclein aggregates in cerebrospinal...
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Measuring Alpha-Synuclein in Extracellular Vesicles, 2024Development of an Alpha-synuclein Blood Biomarker for Clinical Use
Study Rationale: In Parkinson’s disease (PD), alpha-synuclein forms abnormal clumps in nerve cells, causing their death. By the time people develop PD, these alpha-synuclein aggregates have spread...
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ASAP 2020, 2024Parkinson5D: Deconstructing Disease Mechanisms Across Cells, Space and Disease Progression
Study Rationale: Genome-wide association studies (GWAS) have unequivocally linked thousands of genetic variants to susceptibility for common, genetically complex Parkinson’s disease (PD), which...
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Accelerating Biological Understanding and Therapeutic Translation for PD-Biology, 2024Evaluating the Neuroprotective Factor REST as a Target for Parkinson’s Disease
Study Rationale: Studies have shown that a regulatory factor called REST could promote the survival of neurons in neurodegenerative conditions. This factor is produced in greater quantities with age...
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Our funding programs support basic, translational and clinical research from academia and industry.