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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Molecular Mechanisms of Dyskinesia in Parkinson's Disease, 2004
    In Vitro Electrophysiological Studies in Experimental Models of Dyskinesias

    Although levodopa is one of the most effective therapies for Parkinson’s disease, particularly in the early stages, chronic treatment leads to the development of dyskinesias or movement abnormalities...

  • MJFF Research Grant, 2006
    PDGene

    Parkinson’s disease is a genetically complex and heterogeneous disorder. To date, mutations in five genes have been identified to cause early-onset parkinsonism, which typically follows Mendelian...

  • The Role of Inflammation in Parkinson's Disease, 2003
    Inflammatory Mechanisms & PD Risk: A Discordant Twin Pairs Case-Control Study

    The cause of Parkinson’s disease is unknown. A genetic cause is identified in only a small percentage of cases. We believe that environmental factors play an important role in most cases of PD. While...

  • MJFF Research Grant, 2006
    California Parkinson's Disease Registry Pilot Project

    Much remains to be elucidated about causes of Parkinson’s disease, a progressive neurodegenerative condition that affects at least 1,000,000 people in the United States. For example, little detailed...

  • Community Fast Track, 2002
    Proactive action of the peroxisome proliferator-activated receptor-gamma agonist pioglitazone in a pre-clinical model model of Parkinson's disease

    Recently, in mouse studies the peroxisome proliferator-activated receptor-g (PPARg) agonist pioglitazone was shown to be effective in blocking the substantia nigra (SN) cell loss induced by MPTP in a...

  • MJFF Research Grant, 2005
    Nebraska Parkinson's Disease Registry

    The American Parkinson Disease Association (APDA) and The Michael J. Fox Foundation for Parkinson's Research (MJFF) are co-funding the Nebraska Parkinson's Disease Registry with a three-year...

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