The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Rapid Response Innovation Awards, 2007A Novel Strategy for the Selection and Transplantation of Dopamine-Specified Human Embryonic Stem Cells
In Parkinson’s disease (PD), neurodegeneration is largely confined to one discrete group of nerve cells that produce the chemical dopamine (DA). Since the death of most DA neurons almost always...
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Community Fast Track, 2005Specific Inhibition of Nucleation of Alpha-synuclein Aggregation as a Therapeutic Strategy
There is considerable evidence that aggregates of the human brain protein alpha-synuclein are a primary cause of the loss of neurons in Parkinson's disease. We have tried to find out what initiates...
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Community Fast Track, 2007Neoangiogenesis and Blood-Brain Barrier in L-DOPA-Induced Dyskinesia
Levodopa is still the most effective treatment for Parkinson's disease, but has a great potential to induce abnormal involuntary movements (dyskinesia).
Working on a pre-clinical model of PD, we have...
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Community Fast Track, 2005Use of NR2D-selective NMDA Receptor Modulators in the Treatment of PD
The frontline pharmacological treatment for Parkinson’s disease is associated with serious side effects, creating a need for new therapeutic strategies. Recent evidence suggests that selective...
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Community Fast Track, 2006Investigating Defects in Mitochondrial Functions, Transport, Fusion/Fission in LRRK2 Pre-clinical ModelsThe study of genetic forms of Parkinson’s disease is important for revealing the mechanisms of pathogenesis, and for future therapeutic developments. LRRK2 is the recently identified gene for Park8...
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Rapid Response Innovation Awards, 2007Aberrant Striatal Morphology: Impact on Therapeutic Efficacy in PD
While recent clinical trials of neural grafting for Parkinson’s disease (PD) are disappointing, rationale for "replacing" brain cells lost to disease remains strong. Many issues thought to underlie...
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Our funding programs support basic, translational and clinical research from academia and industry.