Ovidiu C. Andronesi, MD, PhD

I am an Associate Professor of Radiology at Harvard Medical School and Director of Multinuclear MR Imaging at Massachusetts General Hospital. My research focuses on the development and application of molecular imaging methods using magnetic resonance imaging (MRI) and magnetic resonance spectroscopic imaging (MRSI) to investigate brain tumors, neurological and psychiatric diseases. I developed in vivo non-invasive MR imaging methods that provide quantitative estimation of neurotransmitters, brain metabolites, phospometabolites and macromolecules. Our highly innovative methods allow fast high-resolution metabolic imaging with robust performance in patients.  I pioneered in-vivo imaging of 2-hydroxyglutarate (2HG) to genotype isocitrate dehydrogenase (IDH) mutations in glioma. These imaging methods enable precision-personalized medicine and were used to accelerate first-in-human clinical trials of targeted therapy. We were awarded two patents (US 8,698,496 andUS 10,012,709) and a pending patent (2014P04710US01) for innovation of our work.