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Integrative Genomic Approach to Discover Disease Mechanisms Underlying Parkinson’s Disease
… Objective/Rationale: Complex diseases such as Parkinson’s are caused by a combination of genetic, environmental and lifestyle factors that all lead to different causal regulation … DNA methylation, and histone modification data from the prefrontal cortex of 550 individuals from two prospective …
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PPMI Data Shows Brain Changes Linked to Parkinson's Progression
August 2, 2017
… A Parkinson's biomarker , or measure to track disease activity, could help researchers and … had increased fluid in the substantia nigra brain region, where dopamine cells die in Parkinson's. This fluid buildup … saw greater progression of motor symptoms over time compared to those without dopamine loss. They reviewed data …
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More Alpha-Synuclein in Spinal Fluid Linked to Faster Cognitive Decline
March 17, 2014
… are analyzing biosamples (spinal fluid, blood, tissue) to make a connection between alpha-synuclein and risk, onset … for up to eight years. In this latest analysis, researchers compared alpha-synuclein levels to scores from tests of … “Taking Inventory of Parkinson’s and Alzheimer’s Disease,” where experts will discuss cognitive decline. Maggie Kuhl …
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Discovery+ Goes on a Timeless Journey Through “Expedition: Back to the Future” to Support MJFF
March 22, 2021
… a time machine…out of a DeLorean?” In the iconic film Back to the Future , Marty McFly is shocked to hear how his … to benefit the Foundation and its work to speed a future without Parkinson’s disease. “Great Scott!” Check out a … , Instagram , Twitter and LinkedIn . Kristina Magana Communications Officer …
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Flip Parkinson's with Team Fox and MJFF Staffers!
June 25, 2012
… Aquino, are hosting their very first fundraising event together! It will be a fun night of flip cup and beirut at … from 6:30-9:30pm for a flippin’ good time. Tickets cost $50 with net proceeds benefitting The Michael J. Fox Foundation. Visit their Team Fox page for details and to register. …
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Identifying Protein Changes Associated with Parkinson’s Disease: Proteomics Public Data Compilation
… Study Rationale: Accumulation of toxic protein aggregates is a hallmark of neurodegenerative … seek disease-modifying therapies. Study Design: We will compile data from all of the recent proteomic studies that … and model). We will then generate a central repository where all the sum mary statistics for all those studies will …