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A Novel Animal Model to Identify the Contribution of Iron Mismanagement to Neurotoxicity and a-synuclein deposition in Basal Ganglia
… Iron in the substantia nigra is an etiological factor in PD. In addition, iron is established as a key … of the importance of ferritin, an animal model that overexpresses ferritin in the dopaminergic neurons of the … strategies for neurotoxin exposure and PD. Final Outcome Dr. Connor examined models with reduced H-ferritin …
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Michael J. Fox Foundation Commits up to $3.8 Million to Develop Gene Silencing Neuroprotective Treatment for Parkinson's Disease
January 4, 2007
… NEWYORK, NY — The Michael J. Fox Foundation has committed up to $3.8 million for the development of a gene silencing … (RNAi) is a natural mechanism present in all cells whereby small RNA molecules (the siRNAs) specifically …
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MJFF Joins Consortium to Develop Model of Parkinson’s Progression
May 19, 2016
… has joined a multinational consortium that will work to create a model of Parkinson’s progression to help design … the MJFF-led Parkinson’s Progression Markers Initiative comprising nearly 1,000 participants, which has made its … on clinical studies investigating Parkinson's progression, visit the MJFF clinical study matching tool Fox Trial Finder …
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Turner Classic Movies Goes “Back to the Future” to Honor the Film’s 35th Anniversary in Parkinson’s Awareness Month
April 14, 2020
… “Great Scott!” Standing the test of time, the beloved ‘80s sci-fi film “Back to the Future” marks its 35th anniversary from landing on … Parkinson’s Awareness Month by featuring a special commercial in honor of Michael J. Fox’s iconic role in the …
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Sleep Disorder Linked with Parkinson's Disease
April 28, 2014
… People with a sleep disorder that causes them to act out dreams … a brain disease, including Parkinson's disease, according to a recent study. Past research has suggested that people …
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Gene-Environment Interaction in PD: Predicting the Onset, Prognosis and Response to Treatment
… Parkinson's disease is a complex and heterogeneous disorder. Discovery of genes that result in rare inherited forms of PD has led to new insights into the cause of disease and the promise of … and environmental exposures on PD, in the framework of prevention. The study will be powered by an unprecedented …