… pathological aggregations in the brains of the more common non-familial PD patients has triggered a significant … we still do not know how the alpha-synuclein protein causes toxicity in the affected dopamine neurons. Thus, the present … entering into very debilitating end stage disease period where the quality of life is poor but instead remain as …

… of the protein alpha-synuclein. One of the main pathways to remove excess amounts of alpha-synuclein, which can be … PD brains and implant them in the brain of these models. Comparing models where LAMP2A is upregulated and in control models (normal …

… Remember Kerry Twibell ? We introduced you to her before the holidays as she was gearing up for her … as we were ascending on summit day, I saw the sun begin to come up on top of the clouds and over the Shira peak, which … climbers – AND that seemingly straight vertical ascent is where you are headed! That leg of the journey takes about …

… Study Rationale:  We have previously found a panel of 8 proteins that can be measured in the blood that together distinguish people who have Parkinson’s Disease vs. … findings into a clinically-available tool.   Final Outcome    … Access to Data and Biospecimens …

… There is a pressing need for new treatments to address cognitive impairment in Parkinson’s disease, yet … improvements for patients. A performance-based assessment, where patients are observed performing activities of daily … Future projects would involve using the UPSA as an outcome measure for a treatment trial evaluating functional …

… “Family and friends always come first.” That’s what Tucker Wilson’s parents instilled … siblings growing up. “We won the lottery when it comes to parents,” he says. “They were our role models.” Tucker’s mother Sandra lived with a form of atypical Parkinson’s — conditions that have …