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Targeted Disruption of TRIM28 to Reduce Alpha-synuclein Levels
… Objective/Rationale: We have previously performed a screen to find new pathways that may regulate alpha-synuclein, the … or even halt the progression of the disease. Anticipated Outcome: By understanding how TRIM28 regulates alpha-synuclein levels, we hope to …
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Your Elected Officials, Your Voice: Coming Together to Speed a Cure
May 18, 2022
… The Michael J. Fox Foundation (MJFF) has a team in Washington, D.C. and grassroots advocates in all 50 states who work with state and federal elected officials on work that complements and supports the Foundation’s mission to end … shaping legislation that affects the entire community and gets us closer to a cure. Share your voice with Congress and …
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What We Fund: $13.7M to Studies toward Measuring Mobility Outcomes and Profiling Genes in Parkinson’s
June 23, 2023
… The Michael J. Fox Foundation (MJFF) awarded 61 grants that total more than $13.7 million in April and May. These … PhD, at the University of Dundee in Scotland. His study shows that the gene can modify a class of proteins called Rab … the PPMI team. Karen Wu Associate Director, Research Communications …
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Write a Letter of Thanks to Invaluable Clinical Trial Participants
December 10, 2012
… (PPMI) is a landmark observational study designed to help define biomarkers – or indicators – of Parkinson’s … have enrolled to participate in PPMI, and in doing so, committed themselves to an extensive battery of tests and assessments over a five-year period. Many clinical …
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Go Back to the Future with Cast Reunion in London
June 5, 2015
… This summer, Team Fox members and Back to the Future fans alike have an opportunity to go where … roads. In honor of Back to the Future ’s 30th anniversary, Showmasters, the creators of London Film & Comic Con (LFCC), have created an “Up to 88!” Team Fox …
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Higher Caffeine Linked to Lower Parkinson’s in LRRK2 Mutation Carriers
October 6, 2020
… Increased caffeine intake is linked to a decreased risk of Parkinson’s disease (PD) in people … between caffeine and PD, this study is one of the first to show possible benefits of caffeine in people with a genetic … mutations are a major risk factor for PD. But they have incomplete penetrance, meaning that not everyone carrying this …