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Understanding and Manipulating Cellular and Circuit-level Vulnerability to Neurodegeneration in Parkinson’s Disease
… Parkinson’s disease (PD) develop untreatable cognitive symptoms due to changes in the brain’s cerebral cortex. These … that networks of nerve cells in the cerebral cortex become dysfunctional because of damage caused by toxic … the disease process will also enable diagnostic tests to predict disease and therapeutic outcomes and to monitor the …
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Interpretation of Accelerometer Data with Deep Learning
… Study Rationale: In-home monitoring of the severity of Parkinson's disease (PD) may help guide therapeutic decisions and prevent life-threatening falls. Deep learning is the … tool for analyzing time-series data. This technique teaches computers to classify items. The aim of this study is to …
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Foundation Honors Three Scientists with Research Prizes
November 15, 2016
… legacy of renowned scientist in the fields of Huntington's and Parkinson's disease research, Dr. Ira Shoulson. … for key scientific discoveries in dystonia , the third most common movement disorder affecting 500,000 adults and … on Parkinson's patient-reported outcomes and patient preferences. The prizes were conferred by Michael J. Fox, …
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A Good Deed to Honor My Grandfather
October 25, 2012
… When Mark Sigel, age 12, of Pepper Pike, Ohio, set out to undertake his Bar Mitzvah project, he immediately thought … living with Parkinson’s. A Bar Mitzvah is, of course, a coming of age ritual in the Jewish tradition, and often, … Mark explains, since one meaning of the word “mitzvah” is “good deed.” “It means a lot to me that I can do good deeds …
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A Virtual Roundtable for Father’s Day: Adult Children Reflect on Having a Father with Parkinson's
June 18, 2020
… Ninja Warrior and MJFF Board member Akbar Gbajabiamila — to discuss how they each have navigated having a father with … was to be his external executive functioner sometimes, where I would tell him ‘slow down, take a breath…’ it’s a … Fox] at, I can deal with it. I know that it makes him more comfortable knowing that everyone is on the same page and …
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Repurposed Drug Shows Promise in Early Studies to Stop Parkinson’s Progression
October 10, 2014
… shown promising results for treating Parkinson’s disease in pre-clinical models. Gaucher is caused by a mutation in the … number of Parkinson’s cases, and reduced GCase is thought to contribute to alpha-synuclein accumulation. Clumps of the … from the University of California, Los Angeles tested the compound AT2101 to increase GCase activity. MJFF funded part …