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Developing a Strategy to Determine Why Melanoma and Parkinson's Disease Occur Together
… The cellular basis for this association is not known. To identify the key cellular events that enhance this shared … risk, we will develop a microscopic approach for examining how melanoma progression is altered in a preclinical model … factors for PD. This strategy will allow us to quantify and compare interrelationships between nerve cells, vasculature …
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LIMP-2 as a Scaffolding Protein to Characterize PD-Associated GCase Variants
… grant: Structural Characterization of the GCase/LIMP-2 Complex Promising Outcomes of Original Grant: Our original … (GCase) and its transporter LIMP-2. About seven to 12 percent of Parkinson’s patients carry mutations in the … protein complexes will eventually shed light on how the mutations influence complex stability and thereby …
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Dyskinesia: What to Do about Moving Too Much
January 21, 2016
… Home Page Cancel Register for Webinar Dyskinesia: What to Do about Moving Too Much First Name Last Name Email … had PD I am a researcher, clinician or work with the PD community Other Diagnosis Date ${selected} Jan Feb Mar Apr … ongoing research into anti-dyskinetic therapies. Target Audience This educational activity is designed for …
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Drug Repurposing: Testing a Drug Approved for One Disease for Its Efficacy in Another
July 20, 2017
… Email Postal Code What is your primary connection to Parkinson's? ${selected} I have PD Immediate family … had PD I am a researcher, clinician or work with the PD community Other Diagnosis Date ${selected} Jan Feb Mar Apr … talk about why we need to test these drugs in Parkinson's, how they're identified and go through some in the pipeline. …
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From Functional Maps to Clinical Outcomes: Interpreting GBA1 Variant Effects in Parkinson's Disease
… in the GBA1 gene are among the most important risk factors for Parkinson’s disease. GBA1 encodes an enzyme that … to toxic build-up of proteins like alpha-synuclein. However, most patient variants remain unclassified, making … data from large populations. Hypothesis: We believe that combining functional assays, neuronal models, and genetic …
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From Clinic to Course: Joellyn Fox Runs Boston
… From Clinic to Course_Joellyn Fox Runs Boston.pdf …