… Objective/Rationale: The goal of this research project is to develop and validate a blood test … related individuals (genetic controls). Relevance to Diagnosis/Treatment of Parkinson’s Disease: One of the key … are likely to develop PD at a point in the future and this early identification provides a window for initiation of …

… determine the best conditions for their use. Relevance to Diagnosis/Treatment of Parkinson’s Disease:   Inherited or … within cells LRRK2 is localized. This will serve to focus research efforts (and future therapies) on a smaller range … Research Tool …

… that transplanting our lab-grown neural circuits into preclinical models for PD will demonstrate significant therapeutic potential that may translate into a treatment for individuals with PD. Study Design:  We … on behaviors related to the motor symptoms of PD. Impact on Diagnosis/Treatment of Parkinson’s disease:  If successful, …

… Study Rationale: Aggregation of the protein alpha-synuclein into fibrils in Lewy bodies and Lewy neurites is the key … alpha-synuclein has been challenging and has limited early diagnosis of PD and clinical trial design.  Hypothesis: We … Research Grant …

… these proteins from a biologically functional state into toxic, fibrous deposits in the brains of people with … effect in a mouse model of tau aggregation. Impact on Diagnosis/Treatment of Parkinson’s disease: Our project … Our small-molecule tau aggregation inhibitor could be moved into preclinical studies to determine its safety and …

… develop PD later in life. Hypothesis:  We hypothesize that early biological changes in PD can be detected years before clinical diagnosis and that these changes can be monitored over time … enhance our understanding of the mechanisms driving the early progression of PD, unveil and prioritize novel drug …