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Fox Insight Brings Research to You, at Home
June 4, 2020
… The following story appeared in our Spring/Summer 2020 edition of The Fox … this story and more, download the full edition . When it comes to understanding Parkinson’s disease (PD) and … it’s vital to integrate the perspectives of people living with the disease. When Michael J. Fox launched the …
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Increasing Endogenous Neurogenesis Using Neurosteroids: A Novel Therapeutic Strategy to Treat Parkinson's Disease
… brain chemical that increases the generation of new neurons to replace the damaged neurons in Parkinson disease (PD). … and reverses the deficits of cognitive function in a pre-clinical model of Alzheimer’s disease. In this study, we … drug as a treatment for Parkinson’s disease. Anticipated Outcome : We anticipate that this chemical will reduce the …
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From Functional Maps to Clinical Outcomes: Interpreting GBA1 Variant Effects in Parkinson's Disease
… in the GBA1 gene are among the most important risk factors for Parkinson’s disease. GBA1 encodes an enzyme that … variants remain unclassified, making it difficult to predict risk or guide treatment. This project builds on our … data from large populations. Hypothesis: We believe that combining functional assays, neuronal models, and genetic …
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MJFF Brokers Industry Consortium to Advance Disease-modifying Therapies
February 4, 2015
… view of the research landscape and our unbiased dedication to meeting patients’ needs allows the Foundation to lead … The Foundation has united three powerhouse pharmaceutical companies for a pre-competitive consortium to characterize the effects of …
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Lehigh University Senior Honors Mom with Local 5K for Team Fox
September 25, 2012
… Kelsey Zeswitz has always looked up to her mom, Chrissie. Now more than ever, Kelsey draws … her field hockey team and others within the student-athlete community to organize this event. “From a young age, my … in the Lehigh Valley Fox Trot 5K on October 28th, simply visit Kelsey’s Team Fox page and make a $20 donation to …
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Biochemical Analysis and Structural Determination of LRRK2 with Kinase Inhibitors
… pharmacological and surgical treatments are available to manage the symptoms of Parkinson’s disease (PD), none yet … especially of any regions containing the kinase domain in complex with small molecule inhibitors. The study is … Steps for Development: Optimized LRRK2 inhibitors will be tested in clinical models of PD with either wild-type or …