-
Caspase- 1 Inhibition to Reduce Cleaved Alpha-synuclein in Pre-clinical Models of Parkinson's Disease
… (α-SYN) at mRNA and/or protein levels within the SN and restore impaired function of the dopamine system in two … over expressors, α-SYN knockouts, and wild-type) will comprise Experiment Groups (1-2) of one month old transgenic … in culture. The present study will see whether we can get similar neuroprotection of nigral neurons in two …
-
Understanding and Manipulating Cellular and Circuit-level Vulnerability to Neurodegeneration in Parkinson’s Disease
… with Parkinson’s disease develop untreatable cognitive symptoms, including problems with attention, decision-making, … the cellular networks required for normal brain function; however, the relationships between alpha-synuclein, … that networks of nerve cells in the cortex of the brain become dysfunctional because of damage caused by pathological …
-
The Michael J. Fox Foundation to Fund $2 Million for Study of Midbrain System
October 22, 2003
… The Michael J. Fox Foundation for Parkinson’s Research today announced that it has committed $2 million to a research initiative supporting … stem cells. “Right now we do not know enough about how dopamine neurons survive and connect within developing …
-
Searching for Early Signs of Parkinson’s Disease in Genetics and How We Sleep, Smell and Digest
May 24, 2012
… Understanding the disease process taking place before symptoms occur could have major implications for early diagnosis … currently funding studies that aim to find out more about how REM Sleep Behavior Disorder (RBD), heart rate … who are investigating whether the disorder might share a common underlying cause with PD. One hypothesis holds that …
-
Breaking News from D.C.: President Biden Has Signed the National Plan to End Parkinson's Act Into Law
July 2, 2024
… President Biden signs the National Plan to End Parkinson's Act into law. Photo courtesy of the Biden … parkinsonisms today and in the future. The Parkinson’s community — including tens of thousands of policy advocates, … — rallied together to help policymakers understand just how critical this legislation is. From adding your names to …
-
Researchers to Share Genetics Data Through the Edmond J. Safra Global Genetics Consortia
July 26, 2004
… J. Fox Foundation for Parkinson’s Research (MJFF) announced today that it has awarded approximately $1.2 million to fund … Consortia initiative. The field of genetics research has become increasingly vital to understanding the disease as … in PD Five investigators at five institutions will analyze how environmental exposures interact with genetic …