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2nd Annual Shaking with Laughter Event To Be Held September 22nd!
September 12, 2012
… featured jazz guitarist John Pizzarelli and his quartet and comedian Dave Coulier and sold out a 500 seat theater. This … at the 1,000 seat Ohio Theater at Playhouse Square in downtown Cleveland. The event will feature 3 time Grammy winning … comedian Jake Johannsen who has appeared on the Letterman show over 40 times. There will be an online auction at …
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Upcoming Hot Topics Webinar: PD Research in 2012 – How Far We’ve Come, and What Lies Ahead
November 29, 2012
… disease (PD) research, but there is still much work to do to find better treatments for the people that need them. In … projects and critical milestones expected in the year to come. We look forward to an engaging, interactive …
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SUPPLEMENT | CMA as a Means to Counteract Alpha-synuclein Pathology in Non-human Primates”
… upon the research from a prior grant: Chaperone-mediated Autophagy to Counteract Alpha-synuclein Pathology Study … preclinical, non-human primate synucleinopathy model by targeting the pathway’s LAMP2A receptor. Our data show that overexpressing LAMP2A protects dopamine neurons …
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Development of an HTS Assay to Break the Alpha-Synuclein-Glucocerebrosidase Feedback Loop
… Objective/Rationale: We aim to develop a novel screening platform to identify candidate … Novel drugs that interfere with this link could thus have show potential as future disease-modifying therapies. Project … microscopy. With such an assay, large libraries of compounds can be screened in the future, to identify …
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Michael J. Fox Foundation Awards $4.6 Million to Help Advance Neurotrophic Factors as Transformative Parkinson's Treatments
June 22, 2010
… NY — The Michael J. Fox Foundation for Parkinson’s Research today announced $4.6 million in awards to support two … early-phase clinical trials of trophic factors have shown potential to slow or stop the progression of … the efficacy of neurotrophic factor therapies. A complication in developing trophic-based therapies is the …
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Evaluating Use of a Spinal Cord Prosthesis to Alleviate Locomotor Deficits in Parkinson’s Disease
… the past two decades, we have developed a therapy that restores walking after paralysis due to a spinal cord injury. … using external sensors attached to the legs. We recently showed that this therapy also alleviates gait impairments and … for alleviating gait deficits. For this purpose, the company ONWARD medical developed the first implantable …