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Analyzing Data from the Parkinson’s Progression Markers Initiative to Identify Subtypes of Parkinson’s Disease
… clinical manifestations makes the disease more challenging to diagnose and treat. The goal of this project is to … disease.) We will use the most powerful methods of computer analysis (i.e., machine learning methods) to group … disease: Knowing PD subtypes can help us better understand how Parkinson's progresses differently from person to …
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MJFF Awardee Builds on Foundation Funding to Land $8 Million Follow-on Award from NINDS
October 3, 2011
… Clinic Arizona announced an $8 million, five-year grant from The National Institute of Neurological Disorders and Stroke (NINDS) to support a "National Brain and Tissue Resource for … Disease and Related Disorders." The announcement comes on the heels of ongoing support from The Michael J. …
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Ask Us Anything: Answers to Your Questions about Gut Health and Parkinson’s (Webinar Audio)
November 1, 2023
… are some of the more bothersome but less talked-about symptoms of PD. In this audio from our Third Thursdays Webinar, … Dolhun, MD, DipABLM, MJFF senior vice president of medical communications, leads a discussion with panelists: Wael … researcher and founder of the Parkinson’s Disease Gastrointestinal Clinic in Pasadena, California Claudia Revilla, …
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Study: Specific Combined Genetic and Environmental Factors Lead to 11-fold Risk for Parkinson’s Disease
October 15, 2012
… long been believed that there is a link between exposure to pesticides and developing Parkinson’s disease (PD), and … newly-released results into an herbicide called paraquat show that PD risk is doubled in people who worked with the … study, however, supports the idea that PD is caused by a combination of genetic and environmental factors . The team …
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Studying the Impact of Alpha-synuclein on Fatty Substances to Identify New Parkinson's Disease Drug Targets
… and breakdown in the cell). Our own studies have shown an interplay between lipids, fatty acids and … with a protein called stearoyl-CoA desaturase) promises to slow it. While interactions of alpha-synuclein and lipids … to define their contribution to PD and their potential to become therapeutic targets. Impact on Diagnosis/Treatment of …
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Inhibiting Programmed Cell Death to Reduce Axonal Degeneration and Brain Inflammation in Parkinson's Disease
… that a programmed cell death pathway called necroptosis is involved in this axonal degeneration, and that key components of the necroptotic cascade, including an enzyme … and genetic methods. This approach will allow us to compare how inhibiting RIPK3 in neurons versus immune cells …