… Study Rationale:        An early diagnostic test to identify those with Parkinson’s disease (PD) and to intervene with therapies as early as possible is a critical unmet need. Recent studies … these patients taken for various reasons prior to their PD diagnosis, and we have taken cerebrospinal fluid (CSF) …

… cells. These changes may also provide additional insight into the mechanism of disease and fuel the discovery of … new genes associated with Parkinson's disease. Impact on Diagnosis/Treatment of Parkinson's disease: This study may reveal new blood biomarkers that could aid in early detection and diagnosis of Parkinson's disease. This …

… Rationale: This project aims to find biomarkers for the diagnosis and prognosis of Parkinson's disease (PD). Levels … expressing alpha-synuclein may potentially represent an early stage of the disease in the peripheral system prior to … expressing alpha-synuclein as a marker for pre-symptomatic, early detection of PD. …

… and the buildup of harmful proteins. For many years, researchers focused on a protein called alpha-synuclein as … protective role, creating a harmful cycle that may drive early brain damage. Hypothesis: PINK1 and tau trap brain … where treatment may work best will be identified. Impact on Diagnosis/Treatment of Parkinson’s …

… your perspective on life," says Dan. "We had a few tears early on, but our attitude was, 'we're going to figure this … going to do and make the best of it'," recalls Dan. Their research brought him and his family to The Michael J. Fox …

… to the development of novel strategies for treatment and early diagnosis. He invented and developed Protein Misfolding … 800. He is ranked 6 in the U.S. among PIs of NIH-funded research studies in neurology, according to the Blue Ridge …