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Mitochondrial DNA Damage in a Pesticide-exposed Cohort
… Rationale: Environmental poisons may cause or contribute to some cases of Parkinson’s disease (PD). Mitochondrial … amount of damage these toxins may have caused. An accurate test is needed. Hypothesis: We will test the hypothesis that damage to mitochondrial DNA (mtDNA) is greater in people who were exposed to certain …
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Distribution of a Dominant-negative Inhibitor of Tumor Necrosis Factor
… developed for disorders of the central nervous system (CNS) to reach therapeutic concentrations in the brain. Therefore, … controlled and targeted delivery of therapies for treating complex CNS disorders such as Parkinson’s disease. Project … necrosis factor (TNF), holds promise as a therapy for PD. However, clinical development is largely hindered by an …
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Coalition Charts Path for Therapies That Slow or Stop Parkinson's
May 27, 2025
… has generated a number of treatments aimed at treating symptoms of the disease, primarily by addressing dopamine … Similarities and differences between synucleinopathies How to measure long-term benefits of treatments that slow … May 2025. The report notes why it’s so important to fully comprehend the benefits of DMTs: As of this writing, it is …
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Using Neurophysiology as a Stratification Tool for Synucleinopathy
… for Parkinson’s disease (PD), the current methods used to identify people suitable for clinical trials are costly, … stimulation (TMS) — to assess neurophysiological markers. Combining these techniques may help to reveal the … measurements to quantify cortical brain activity. The TMS test will be paired with nerve stimulation to measure …
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Hitting the Road in 2025: Championing Community Fundraising at Every Stop
December 10, 2025
… From left to right: Alexandria, Kate, Duyen and Kylie at Kate's Team … (DIY) staff hit the road — crisscrossing the country to show up for the community-led events that power our mission. From rides and …
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Michael J. Fox Foundation Seeks Innovative Scientific Approaches for 2006 Community Fast Track Program
March 30, 2006
… J. Fox Foundation for Parkinson’s Research announced today the launch of its 2006 Community Fast Track research program (CFT ’06). This annual … conducted within a one-year timeframe and a $125,000 budget. This puts a greater emphasis on speed and outcomes, …