… Study Rationale:  Activating mutations in LRRK2 are a common cause of Parkinson’s disease (PD). We propose using aptamers to inhibit LRRK2. Aptamers are snippets of DNA or RNA that can fold into shape that allows them to bind …

… The biology behind what causes Parkinson’s disease (PD) is complex, with only about a quarter of cases with clear genetic drivers. The environment – where you live, the air you breathe, the food you eat, the … in PD. Emerging research is showing environmental exposures to things like pesticides and pollution may interact with a …

… Today we launched a new website for The Michael J. Fox … was led by the Foundation’s Digital Strategy team and the Communications team in collaboration with Ruder Finn … (RFI). Our hope is the new site creates a platform where Parkinson’s patients, caregivers, supporters and …

… several important cellular mechanisms and may contribute to neurodegeneration. To recover GCase activity, we propose to use small molecules called non-competitive pharmacological chaperones that specifically … assays, several compounds have been selected to be tested in PD cellular models by the second team: experts in …

… disease (PD) is characterized by impairment of motor control as a result from extensive neuron death. The … from families who have a genetic form of PD that is accompanied by a mutation (change in genetic material, or DNA) … the direct contribution of this pathway to PD using a pre-clinical model of idiopathic PD (cause of PD unknown). …

… Editor's Note: For more Foundation news and research updates, … and her father had Parkinson's disease (PD). She made a commitment to research by joining clinical studies, … absolutely is." To learn more about planned giving at MJFF, visit plannedgiving.michaeljfox.org. To chat about the …