The Foundation supports research that can lead to the creation of better Parkinson's treatments. Here you can search previously awarded grants by keyword, program name, researcher name, institution or organization name and/or year.
ALL FUNDED GRANTS (1273)
Biomarker Development, 2015
Our project aims to develop a brain imaging agent for alpha-synuclein, a key protein involved in Parkinson's disease (PD) pathology. Such an agent will help (i) diagnose PD earlier, (ii) track pathology over time and (iii) monitor the efficacy of therapeutics reducing alpha-synuclein aggregates. The AC Immune team identified promising compounds that will be refined to target such a...
Rapid Response Innovation Awards, 2014
Although the causes of Parkinson's disease (PD) are yet unknown, the overall health of the body likely plays a major role in disease initiation and progression. However, maintenance and/or restoration of normal systemic activity have been largely overlooked by current pharmaceutical treatments — an approach that has led to a scarcity of effective disease-modifying ...
Research Grant, 2014
Mutations in GBA1, the gene encoding the protein glucocerebrosidase, represent a common genetic risk factor for developing Parkinson disease (PD). PD patients with and without GBA1 mutations exhibit lower levels of glucocerebrosidase in the central nervous system (CNS), suggesting a strong correlation between low glucocerebrosidase activity and the development of t...
Researchers: Sergio Pablo Sardi, PharmD, PhD
Parkin Biology, 2014
The protein Parkin contributes to the elimination of damaged mitochondria by a process called mitophagy. Prior research has shown that silencing Parkin gene affects innate immunity, the first line of defense against invading viruses. This project will characterize the mechanisms by which Parkin modulates host immune response. One of the key players in innate immunity is a mitoc...
Researchers: Aleem Siddiqui, PhD
Target Validation, 2014
Mitochondrial dysfunction and oxidative stress contributes to the death of the brain cells seen in Parkinson's disease. The mitochondrial protein mitoNEET (encoded by the gene CISD1) has been shown to modulate mitochondrial biology and oxidative capacity. We hypothesize that mitoNEET plays an important role in the oxidative capacity of brain cells and helps maintain normal mito...