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FUNDED GRANTS

The Foundation supports research that can lead to the creation of better Parkinson's treatments. Here you can search previously awarded grants by keyword, program name, researcher name, institution/ organization name, or year.

ALL FUNDED GRANTS (1164)

 

Access to Data and Biospecimens, 2014

Defining Non-motor Phenotypes in Parkinson's Disease and Novel Strategies for Diagnosis

Objective/Rationale:
Although Parkinson's disease (PD) is diagnosed as a movement disorder, motor deficits are preceded by non-motor features including cognitive, cardiovascular, gastrointestinal, psychiatric and sleep disturbances. Characterizing patterns of such non-motor features in early, medication-nave PD may allow for improved treatment.

Project Description:
This study will use cluster anal...

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Researchers: Samay Jain, MD, MS

 

Research Grant, 2014

Anti-dyskinetic Activity of the Selective 5-HT1A Agonist NLX-112: Behavioral and Microdialysis Studies

Promising Outcomes of Original Grant:
These researchers are investigating the activity of novel drugs that potently activate serotonin 5-HT1A receptors. Targeting this receptor subtype is an attractive strategy to decrease the dyskinesia that arises in Parkinson's disease (PD) patients from prolonged treatment with levodopa. Data gathered in the previous grant showed that a novel, exceptionally sel...

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Researchers: Adrian Newman-Tancredi, PhD

 

Research Grant, 2014

Accelerated Pre-clinical Development of a Novel and Specific Alpha-synuclein Tracer

Objective/Rationale:
Biomarkers that can communicate the underlying pathology of Parkinson's disease (PD) in living patients would be invaluable for diagnosis and for evaluation of disease-modifying treatments. The purpose of this project is to develop tracers for use with PET imaging that can bind to misfolded alpha-synuclein, which is thought to be central to the pathology in PD.

Project Descri...

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Researchers: Giorgio Attardo, PhD, MSc , Andrew Siderowf, MD, MSCE

 

Access to Data and Biospecimens, 2014

Effect of LRRK2 Mutations on PD-associated Inflammation

Objective/Rationale:
Increased inflammation is associated with the progression and possibly even onset of Parkinson's disease (PD). Mutations in the LRRK2 gene are also associated with PD, and recent evidence points to a role for LRRK2 to modulate inflammatory pathways. This project aims to investigate inflammatory cytokines (small proteins involved in cell signaling) in people with LRRK2 mutations...

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Researchers: Nicolas Luke Dzamko, PhD , Glenda Margaret Halliday, BSc(Hons), PhD

 

LRRK2 Role in Idiopathic Parkinson's Disease, 2014

Age-related Alterations in LRRK2 Expression and Function in Immune Cells and Risk for Idiopathic Parkinson's Disease

Objective/Rationale:
The LRRK2 protein is highly expressed in immune cells, but its function is unknown and may change as the immune system changes with aging and environmental exposures, the largest risk factors for idiopathic (cause unknown) Parkinson's disease (PD). This project will test the hypotheses that age-related alterations in LRRK2 levels or function skew the normal activity of innate a...

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Researchers: Malu G. Tansey, PhD

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