The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
-
Understanding LRRK2 Biology, 2009Biochemical Characterization of Full Length Human Recombinant LRRK1 and LRRK2
Objective/Rationale:
Mutations in one gene, LRRK2, are a common cause of Parkinson’s disease. However, the protein product of this gene is large and complex and, to date, no one has been able to make... -
Understanding LRRK2 Biology, 2009LRRK2 Mediated Pathogenic Pathways in Dopaminergic Axonal Degeneration and Synaptic Transmission
Objective/Rationale:
Mutations in the LRRK2 gene occur with high frequency in familial and sporadic Parkinson disease. We have established a R1441G-LRRK2 transgenic pre-clinical model that... -
Understanding LRRK2 Biology, 2009Identification of LRRK2 Substrates in Pre-clinical Models of Parkinson's Disease
Objective/Rationale:
Mutations in the LRRK2 gene are a common cause of familial and sporadic Parkinson’s disease. The LRRK2 protein can function as a kinase in vitro and certain familial mutations may... -
Understanding LRRK2 Biology, 2009Functional Analysis of LRRK2
Objective/Rationale:
LRRK2 is a gene that, when not working properly, causes Parkinson’s disease. However, the function of this large gene and its involvement in the disease process is virtually... -
Understanding LRRK2 Biology, 2009Development of Biochemical Assays for LRRK1
Objective/Rationale:
Studies over the last several years have identified the protein kinase LRRK2 as a potential target for Parkinson’s disease therapeutics. While targeting kinases has been a... -
Biomarkers, 2009T-Cell Receptors Changes as a Biomarker of Parkinson's Disease
Objective/Rationale:
The diagnosis of PD is based on clinical characteristics because there are no reliable blood tests for early diagnosis or to follow the progressive course of the disease. Along...
Apply for a Grant
Our funding programs support basic, translational and clinical research from academia and industry.