The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2013Using Whole Genome Sequencing Data from LRRK2 Families to Identify Novel Rare Variants of LRRK2-associated Parkinson’s Disease
Objective/Rationale:
The age of onset and penetrance (likelihood of disease) of individuals with the LRRK2 G2019S mutation varies considerably, the latter ranging in some families from as high as 100... -
Cognition Biomarkers, 2013Validation of Novel and Traditional Quantitative EEG Biomarkers
Objective/Rationale:
Cognitive problems commonly add to the disability of the motor symptoms of Parkinson’s disease (PD), but there are no highly effective treatments for cognitive dysfunction in PD... -
LRRK2 Challenge, 2013Physiological Role of Lysosomal LRRK2 in the Regulation of CMA
Objective/Rationale:
Brain cells rely on very efficient surveillance systems to identify defective components and break them apart to avoid accumulation and toxicity. Research has shown that in the... -
Target Validation, 2013IL-13Ra1 and Neuroinflammatory Damage in the MPTP Pre-Clinical Model of PD
Study Rationale:
Neuroinflammation has been proposed to contribute to both the pathogenesis and the progression of Parkinson's disease (PD). We recently showed that an important... -
LRRK2 Role in Idiopathic Parkinson's Disease, 2013Phenotype Assay for LRRK2 in Parkinson's Disease Fibroblasts
Objective/Rationale:
Variants of the LRRK2 gene are associated with overactivation of the LRRK2 protein’s activity and an increased risk of Parkinson's disease (PD). We have previously... -
LRRK2 Challenge, 2013Investigating the Role of LRRK2 in Mycobacterial Infection
Objective/Rationale:
Mutations in the LRRK2 gene are the most common known genetic risk factors for Parkinson's disease. Although we know that these mutations can cause Parkinson's disease...
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Our funding programs support basic, translational and clinical research from academia and industry.