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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • GBA Biology and Therapies, 2019
    Sphingolipid and Alpha-synuclein Interactions

    Study Rationale:                   
    The contributions of multiple factors to Parkinson's disease (PD) are not fully understood.  However, it is clear that a normal cellular protein called alpha...

  • Improved Biomarkers and Clinical Outcome Measures, 2019
    Applying Artificial Intelligence for Early Identification of Parkinson’s Disease

    Study Rationale:
    The nervous system regulates heart rate in response to situations such as stress and emergencies. Dysfunction of part of the nervous system controlling the heart can cause changes in...

  • Research Grant, 2019
    Enhancing the Clinical Utility of Data-Driven Parkinson’s Subtypes with Knowledge Distillation and Visualization

    Study Rationale:
    Data-driven analytics, such as machine learning methods, have been applied to discover comprehensive Parkinson’s disease (PD) subtypes from observational patient data. However, many of...

  • Research Grant, 2019
    Measurement of BMP and NAG Activity in CSF Samples

    Study Rationale:
    Mutations in the LRRK2 gene are a common cause of dominantly inherited Parkinson’s disease (PD). Previous studies showed that urine levels of a lipid [di-22:6-bis(monoacylglycerol...

  • Research Grant, 2019
    Mechanistic Characterization of the PINK1-amplifying Compound MTK-458

    Study Rationale:
    Loss-of-function mutations in components of the PINK1/PRKN pathway lead to early onset Parkinson’s disease. Previous work by our company has shown that our compounds can amplify the...

  • Research Grant, 2019
    Supplement: Investigation of PINK1-dependent Phosphorylation of Rab GTPases

    Promising Outcomes of Original Grant:
    We were trying to understand how the PINK1 gene targets a set of proteins known as Rab GTPases through protein modification known as phosphorylation. The highlight...

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