-
Selective Inhibition of Cyclic Nucleotide Phosphodiesterase Type 7 (PDE7): A Novel and Efficacious Approach to Treating Parkinson's Disease
… Type 7 (PDE7): A Novel and Efficacious Approach to Treating Parkinson's Disease Promising Outcomes of Original Grant : We are investigating a regulatory … of Parkinson’s disease. Our findings to date have shown that inhibitors of PDE7 are highly effective in one …
-
Place your Bets at a Star-Studded Table — All to Speed a Cure
September 20, 2013
… will be hosting its inaugural Celebrity Invitational Poker Tournament in Southern California. Hollywood Poker is the … non-virtual table. The live poker tournament takes place at Commerce Casino in Commorco, California. The event is open … was perfect and was a natural fit for us to partner together.” Don Most will be joined this year by many other …
-
Using LRRK2 Computer Simulations to Identify Therapeutic Targets for Parkinson's Disease
… proteins and alters several molecular pathways, including autophagy (cell break down), mitochondria (powerhouses of the … packets) and membrane (outside layer) and synaptic (site of communications) changes. To successfully identify therapeutics with minimal off-target effects, it is important to understand these molecular …
-
Team Fox Young Professionals of Washington DC to Host Golf Event
May 12, 2014
… of DC will co-host the 5th Annual St. John’s Cup Golf Tournament in partnership with St. John’s Lodge of the … Base at 2:30pm. Golfers of all levels are encouraged to come out and enjoy this unique golfing experience! Teams … After the tournament, golfers and supporters will gather together at the St. John’s Cup Banquet where guests will dine, …
-
Bloomberg Businessweek: Sergey Brin Partners with MJFF to Accelerate Parkinson’s Cure Research
May 11, 2012
… Today, Bloomberg Businessweek featured Sergey Brin’s … and the work being done at 23andMe, the personal genetics company founded by his wife, Anne Wojcicki. The article highlights new investments in research targeting LRRK2, the greatest known genetic contributor to PD. …
-
Cofilin-1 as a Major Contributor to Oxidative Stress-mediated Cell Death in Parkinson’s Disease
… Objective/Rationale: Oxidative stress, a process that stops the cell producing energy efficiently, is a key cause … of neurons in Parkinson’s disease. We have previously shown that oxidative stress also occurs in lung cancer cells, … taken from patients who have died with Parkinson’s to compare the amount of cofilin-1 protein and the amount of a …