The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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The Role of Protein Degradation in Parkinson's Disease, 2002Lentiviral Mediated Effect of Chaperones & Parkin in a Genetic Model of Parkinson's disease
The study of familial Parkinson disease indicates that the loss of nerve cells of a brain structure named the substantia nigra may be related to the accumulation of proteins aggregating within these...
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The Role of Protein Degradation in Parkinson's Disease, 2002Regulation of Nurr1 Nuclear Receptor Transcriptional Activity by the Ubiquitin Proteasome System
Parkinson's disease (PD) is a neurodegenerative disease involving progressive and selective death of dopamine producing neurons located in the midbrain. Survival and normal activity of these neurons...
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The Role of Protein Degradation in Parkinson's Disease, 2002Parkin-Mediated Ubiquitination at the Synapse
Parkinson's disease (PD) involves the death of dopamine neurons in the midbrain and leads to devastating motor and functional impairment. Although treatment is available, its effectiveness diminishes...
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The Role of Protein Degradation in Parkinson's Disease, 2002Ubiquitin Conjugates in Parkinson's Disease and Dementia with Lewy Bodies
To adapt to the ever-changing environment, the cell has to consistently make new proteins and degrade those that are no longer needed or toxic to the cell. Removal of intracellular proteins is...
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The Role of Protein Degradation in Parkinson's Disease, 2002Role of Autophagic-Lysosomal Pathway in the Degradation of Alpha-Synuclein Aggregates
Many human neurological diseases, including Parkinson's disease, Alzheimer's disease, and Huntington's disease, are associated with abnormal levels of protein buildup inside brain cells (neurons). A...
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The Role of Protein Degradation in Parkinson's Disease, 2002Proteomic analysis of accumulated proteins in dopaminergic neurons using a pre-clinical model ofubiquitin-proteasome system dysfunction
Damaged or unnecessary proteins are normally removed from a cell after they are tagged by attachment of a small protein called ubiquitin. These ubiquitin-tagged proteins are then recognized by a large...
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