The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Target Validation, 2007Functional Inhibition of RasGRF1 in the MPTP-lesioned NHP Model for Treating Levodopa-induced Dyskinesia
Objective/Rationale:
Levodopa-induced dyskinesias are caused by an increased and aberrant response of dopamine receptors to dopamine in the striatum. Among other intracellular pathways, the MAP kinase... -
Target Validation, 2007Validation of metabotropic glutamate-receptor type 5 as a target for the treatment of L-DOPA-induced dyskinesia in a macaque model of Parkinson´s disease
Objective/Rationale:
Metabotropic glutamate receptor type 5 (mGluR5) is abundantly expressed in striatal neurons, where it modulates the response to glutamatergic and dopaminergic inputs. Previous... -
Target Validation, 2007Inhibition of c-Abl Tyrosine Kinase as a Novel Therapy to Prevent PD ProgressionObjective/Rationale: Mutations in the parkin gene cause early-onset autosomal recessive PD. We have discovered that parkin is modified by an oxidative-stress induced signaling kinase, c...
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Rapid Response Innovation Awards, 2007Unraveling the genetic basis for alpha-synuclein oligomerization in living cells using bimolecular fluorescence complementation
Oligomerization of alpha-synuclein is hypothesized to be the pathogenic mechanism of protein aggregate formation and cell death in neurons of PD patients. Dr. Outeiro proposes to develop an assay to...
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Specification, Patterning, and Maintenance of Midbrain Dopam, 2004Generation and Characterization of Mice with Inducible and Cell-Type Specific Interruption ofGDNF Signaling
The primary goal of this proposal is the generation of two powerful and innovative conditional mouse knockout strains to interrupt GDNF signaling. We propose to conditionally knock out the GDNF...
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Specification, Patterning, and Maintenance of Midbrain Dopam, 2004Small Molecules That Promote Regeneration of Dopaminergic Neurons from Human Neural Stem Cells
For a better understanding of the signaling pathways that instruct neural precursor cells to differentiate into dopaminergic (DA) neurons (which are lost in the brain of Parkinson's Disease patients)...
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Our funding programs support basic, translational and clinical research from academia and industry.