The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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MJFF Research Grant, 2010Regulation of LRRK2 Membrane Association
Objective/Rationale:
Mutations in LRRK2 are the most common genetic cause of Parkinson’s disease. The LRRK2 gene encodes a large multi-domain protein with kinase activity. LRRK2 protein is normally... -
MJFF Research Grant, 2010Patient-specific iPS cell-derived Neurons and Disease-associated LRRK2 Mutations for Parkinson's Disease Research
Objective/Rationale:
Several underlying genetic risk factors are now established for Parkinson’s disease (PD). Mutations in LRRK2 are the most common genetic cause of the selective neurodegeneration... -
MJFF Research Grant, 2010Multi-tracer positron emission tomography (PET) functional imaging as a tool to assess the relevance of rodent LRRK2 models to the human neurochemical phenotype associated with LRRK2 mutations related Parkinsonism
Objective/Rationale:
Transgenic pre-clinical models are instrumental to investigate mutation-induced abnormalities at the bio-chemical, cellular level in a manner not possible in humans. In humans... -
Therapeutics Development Initiative, 2010Development of Nurr1-RXR Heterodimer Selective Agonists for Parkinson's Disease
Objective/Rationale:
Nurr1 is a nuclear hormone receptor strongly implicated in the growth, maintenance, and survival of dopaminergic neurons. No endogenous Nurr1 ligands have been identified, and... -
Therapeutics Development Initiative, 2010HE3286 as Treatment for Parkinson's Disease
Objective/Rationale:
Dehydroepiandrosterone (DHEA), a common neutraceutical and potent neuro-steroid has been suggested as a neuroprotective treatment for Parkinson’s disease (PD). However, DHEA is... -
Therapeutics Development Initiative, 2010Evaluation of the Neuroprotectivity Ability of Zymes' Water-soluble CoQ10 (WS-CoQ10) in Pre-clinical Models of PD; Preclinical Validation and Dose Optimization for Clinical Study
Objective/Rationale:
Coenzyme Q10 is a lipid soluble naturally occurring compound essential for energy production and defence against oxidative stress. Recent clinical studies indicate that it may...
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Our funding programs support basic, translational and clinical research from academia and industry.