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Funded Studies

Matthew Farrer, PhD

Professor at University of British Columbia (UBC)

Location: Vancouver Canada

Professor Farrer holds a Canada Excellence Research Chair in Medical Genetics position at UBC and has contributed many peer-reviewed publications on the LRRK2 gene. His team made several original discoveries relating to the gene, including pathogenic mutations genetically linked with Parkinson’s disease. His group reported the genetic linkage, penetrance and a common founder for LRRK2 G2019S, and postulated increased kinase activity as the underlying mechanism responsible for disease. Current research interests include population genetic analysis of LRRK2 variants, generation of highly specific LRRK2 antibodies and protein biochemistry, cell-based drug screening assays and informative pre-clinical models. Since cloning the gene, his team has provided the plasmid to >50 laboratories, without restriction, and BAC LRRK2 human wild-type and mutant transgenic pre-clinical models and/or tissue to many teams. Professor Farrer is currently involved in natural history, genetic and biomarker studies of LRRK2 patients, including neuroimaging, to perform future clinical trials.


Associated Grants

  • Alpha-synuclein and Cognitive Decline in Parkinson’s Disease

    2013


  • Global Estimates for the Role of LRRK2 Variation in Parkinson's Disease Susceptibility

    2011


  • Multi-tracer positron emission tomography (PET) functional imaging as a tool to assess the relevance of rodent LRRK2 models to the human neurochemical phenotype associated with LRRK2 mutations related Parkinsonism

    2011


  • The Role of LRRK2 in Neurotransmission

    2010


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