To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
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PDGFβ-Human Alpha Synuclein (Line D) Mouse*
Mouse Model
Mice express wildtype human alpha synuclein cDNA driven by the platelet derived growth factor, β polypeptide (PDGFB) promoter. Model was developed by Eliezer Masliah and deposited by Robert Rissman at University of California San Diego, and made available through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:038774
Alpha Synuclein Gene Replacement WT (SNCA-GR WT) Mouse*
Mouse Model
Knock-in/knock-out gene replacement model with mouse genomic regions from Snca exchanged for 158 kb of the human SNCA genomic region. Model was donated by Dr. Michael Koob at University of Minnesota, and made available through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:039166
Alpha Synuclein Gene Replacement A53T (SNCA-GR*A53T) Mouse*
Mouse Model
Knock-in/knock-out gene replacement model with mouse genomic regions from Snca exchanged for 158 kb of the human SNCA genomic region including the A53T mutation. Model was donated by Dr. Michael Koob at University of Minnesota, and made available through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:039167
Alpha Synuclein Gene Replacement E46K (SNCA-GR*E46K) Mouse*
Mouse Model
Knock-in/knock-out gene replacement model with mouse genomic regions from Snca exchanged for 158 kb of the human SNCA genomic region including the E46K mutation. Model was donated by Dr. Michael Koob at University of Minnesota, and made available through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:039168
Ubiquitin pS65 Phosphospecific Antibody (IHC)
Antibody
Rat anti-pS65 Ubiquitin antibody that has undergone Fc species switching to develop rat reagents from the original rabbit antibody (41H1/41K3). The new chimeric antibody is approved for immunohistochemistry and can be detected using Fc-specific secondary antibodies to rat IgG.
Ubiquitin pS65 Phosphospecific Antibody (WB/ICC/ELISA)
Antibody
Rat anti-pS65 Ubiquitin antibody that has undergone Fc species switching to develop rat reagents from the original rabbit antibody (30H3/30K1). The new chimeric antibody is approved for immunoblotting, immunocytochemistry, and immunoassay, and can be detected using Fc-specific secondary antibodies to rat IgG.
Miro1 Antibody (ELISA-Capture)
Antibody
Rabbit monoclonal antibody directed against human/mouse/rat Miro1, validated for use as a capture antibody in immunoassay applications.
Can also be purchased as a pair with the detector antibody here.
Miro1 Antibody (ELISA-Detector)
Antibody
Rabbit monoclonal antibody directed against human/mouse/rat Miro1, validated for use as a detector antibody in immunoassay applications.
Can also be purchased as a pair with the detector antibody here.
Human Alpha-Synuclein Monomer Protein for Making Pre-Formed Fibrils
Protein
Full-Length human alpha-synuclein monomeric protein specially formulated to generate pre-formed fibrils. These highly pure proteins are recommended for biochemical studies and can be used to form fibrils, but these fibrils have been found to lack seeding activity.
Note: A protocol for generating pre-formed fibrils from this monomeric protein will be included with each order.
Mouse Alpha-Synuclein Monomer Protein for Making Pre-Formed Fibrils
Protein
Full-length mouse alpha-synuclein monomeric protein specially formulated to generate pre-formed fibrils. Please note, we recommend this protein for in vitro studies but not for in vivo experiments (the protein is validated for pS129 alpha-synuclein pathology in vitro but in vivo validation failed as robust pS129 alpha-synuclein pathology was not observed). These highly pure proteins are recommended for biochemical studies and can be used to form fibrils, but these fibrils have been found to lack seeding activity.
Note: A protocol for generating pre-formed fibrils from this monomeric protein will be included with each order.
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic