To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
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VPS13C Edited iPSC Lines
Human iPS Cell
KOLF2.1J human iPSC line with CRISPR-engineered mutations in VPS13C, including heterozygous and homozygous G1389R, heterozygous and homozygous R117*, and homozygous knockout mutations. These lines were generated within the iPSC Neurodegeneration Initiative for Parkinson’s Disease (iNDI-PD) which is supported by Aligning Science Across Parkinson's (ASAP). Estimated Availability: Q1 2026.
VPS13C Knockout HeLa Cell Line
Immortalized Cell
HeLa cell with homozygous knockout of VPS13C.
VPS35 D620N Mouse
Mouse Model
Mice expressing the D620N mutant form of VPS35. RRID:IMSR_JAX:023409
VPS35 Plasmids
DNA Plasmids
DNA Plasmids encoding various VPS35 cDNA inserts
Wild Type Human Alpha-Synuclein Mouse
Mouse Model
Mice express a wild-type human alpha-synuclein gene directed by its endogenous promoter/enhancer regions on the BAC transgene. RRID:IMSR_JAX:018442
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"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic