From 2001 to 2009, Alexis Brice headed the Department of Genetics at the Pitié-Salpêtrière University Hospital associated with the University Pierre and Marie Curie (UPMC) medical school. He is also the coordinator of the National Reference Centre for Neurogenetics. He leads the Neurogenetics research group and the DNA and Cell Bank at the Neuroscience Research Center (CRicm) at the Pitié-Salpêtrière Hospital.

He has held positions in a variety of national and international scientific organizations, and is a member of the editorial board of several journals in the fields of Genetics and Neurology.
He is currently Chairman of the Institute for Neuroscience, Cognitive Sciences, Neurology and Psychiatry at Aviesan.

His research, which includes both clinical and basic research, aims at elucidating the molecular basis and physiopathological mechanisms of several hereditary neurodegenerative disorders including Parkinson’s disease, frontotemporal lobar degeneration and spinocerebellar degenerations. He has published over 473 research papers.