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Longitudinal Characterization of G2019S Models: Physiological and Behavioral Analyses of Dopamine and Glutamate Systems
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The Four Horsemen of G2019S
… G2019S variant of LRRK2 are abnormally sensitive to immune system molecules that naturally increase in the body with … … Inflammation … California … LRRK2 … LRRK2 in the Immune System … Theo D. Palmer, PhD …
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Using Machine Learning on Longitudinal Data from Multiple Cohorts to Determine Biological Subtypes and Prediction Scores for Parkinson’s Disease
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Translation of the Neuroprotective Immune Modulator LBT-3627 into First-In-Human Studies
… well as people with PD who exhibit a dysfunctional immune system. Participants will be treated with a single dose of … in terms of future PD clinical trials. … Adaptive immune system … autoimmunity … Clinical trials … disease … tolerance … Inflammation … neuroimmune … peripheral immune system … t cell … 2022: Accelerated Therapeutics Program … …
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Feeding with Clostridium Leptum for Restoring the Integrity of the Striatal Dopaminergic System in a Pre-clinical Model of Parkinson’s Disease
… and reduce toxicant-mediated toxicity of striatal dopamine system. Project Description: In this study, we … neuroprotective effect on MPTP-induced striatal dopamine system toxicity by measuring the concentrations of dopamine …
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Evaluation of the Inflammation-blocking Drug Tolebrutinib as a Novel Disease-modifying Therapeutic for Parkinson's Disease
… the effectiveness of Tolebrutinib in cell culture and in multiple preclinical animal models of PD. We will determine … shown to be safe and well-tolerated in clinical trials for multiple sclerosis. If this project is successful, … … Neuroprotective/Regenerative … peripheral immune system … Therapeutic Pipeline Program … Richard Gordon, PhD, …