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Analysis of Skin Biopsies from the Systemic Synuclein Sampling Study by Alpha-synuclein Seed Amplification Assay
… we propose to analyze existing skin samples from the MJFF Systemic Synuclein Sampling Study (S4). Hypothesis: We …
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The Four Horsemen of G2019S
… G2019S variant of LRRK2 are abnormally sensitive to immune system molecules that naturally increase in the body with … LRRK2 in the Immune System …
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New Biological Definition and Proposed Staging System for PD: What it means for Researchers, Industry Professionals and Clinicians
January 29, 2024
… a publication in Lancet Neurology proposing a new staging system for Neuronal Synuclein Disease (NSD). As part of the … several letters raising questions about the staging system and definition of NSD. On June 12, 2024, Lancet … conversation surrounding NSD and its accompanying staging system. A global team of researchers published a paper in …
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Evaluation of a Monitoring System Based on a Wearable Sensor for Improving Swallowing and Saliva Control in Parkinson’s Disease
… Study Design: We will begin by modifying and improving our system to facilitate future regulatory approval. We will …
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Episode 9: Examining the Proposed Biological Definition of Neuronal Alpha-Synuclein Disease and Staging System with Lana Chahine
February 20, 2024
… (NSD) has been proposed, along with an integrated staging system (NSD-ISS). In this interview, we discuss the … biologic definition for Parkinson’s disease and the staging system with Dr. Lana Chanine, one of the lead authors of the …
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Longitudinal Characterization of G2019S Models: Physiological and Behavioral Analyses of Dopamine and Glutamate Systems