… funding studies that aim to find out more about how REM Sleep Behavior Disorder (RBD), heart rate variability , and …

… Study Rationale:  Disrupted sleep is an early sign of Parkinson’s disease (PD) that … progresses. Chronic symptoms of PD include alternations in sleep patterns and changes in the body’s internal clock, or … of CK1d may resolve circadian disruptions and improve sleep patterns in people with PD, and we have made exciting …

… because of disease onset. Most individuals diagnosed with a sleeping disorder called rapid eye movement (REM) sleep behavior disorder (RBD) are likely to develop PD. By … to monitor and detect potential conversion to PD.  … Sleep Disorders … Inflammation … The Role of Inflammation in …

… alters brain activity involved in movement control and sleep quality. In line with our original hypothesis, we … with the LRRK2 mutation slept less and had more powerful sleep spindles, a form of brain wave involved in maintaining sleep and forming memories. These observations suggested …

… in the brain’s waste clearance mechanisms. Disruptions in sleep, which are common in people with PD, have similarly … PD to investigate how enhancing a particular phase of the sleep cycle can promote natural brain clearance pathways, … that drugs that enhance the “slow wave” phase of the sleep cycle will boost the brain’s waste clearance …

… behavioral disorders, neuropsychiatric issues and sleep disorders, which severely impact quality of life. Our … symptoms, including anxiety, cognitive function and sleep dysfunction. To elucidate the compound's mechanism of … non-motor manifestations. … microglia … Neuroinflammation … Sleep Disorders … Parkinson’s Disease Therapeutics Pipeline …