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The State of Science in Parkinson's Research
November 17, 2011
… body functions. The hope is that, by bypassing the dopamine system altogether, it might be possible to provide the same … research area for MJFF, and we’re tackling it from multiple angles simultaneously to accelerate progress. On … the consortium is studying how LRRK2 may influence immune system response to external triggers of PD, which could …
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Todd Sherer's Testimony at Hearing on NIH and the National Center for Advancing Translational Sciences (NCATS)
March 20, 2012
… Parkinson’s disease. The structure of our drug development system fundamentally impacts every American at some point in … has a great deal of experience with the complexity of this system, I thought I could be most helpful today by sharing … in this space. First: The research enterprise is made up of multiple well-intentioned but differently incentivized …
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Utilizing Novel Tracers to Determine the Distribution of Therapeutic Agents In Vivo
… will utilize a novel programmable pump and catheter system that can improve control of drug dosing and delivery. … disease. Project Description: A novel pump and catheter system for direct infusion to the brain, currently under … in pre-clinical models. The developed pump and catheter system will be surgically inserted into the brain of the …
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Investigating Placebo Effects in Parkinson's Disease with Functional MRI
… on whether placebo treatments actually affect the brain systems disrupted in PD. Understanding placebo effects on … to study placebo effects on the functions of two brain systems related to function and quality of life in Parkinson’s patients, the motor system and the dopamine system. fMRI can measure the …
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GBA Variations, Cholinergic Degeneration, and Cognitive Decline in Parkinson’s Disease
… postural instability and gait disorders. The cholinergic system, a collection of nerve cells that communicate via the … goal is to gain a better understanding of the cholinergic system in GBA-PD and the related clinical symptoms, using … distinct pattern, with more degeneration of the cholinergic system related to the severity of their symptoms, in …
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Effect of SAR-CoV-2 on Experimental Parkinsonism in a Preclinical Model of Parkinson’s Disease
… that in many cases, infection is associated with nervous system involvement, including the central nervous system (headache, confusion, seizure and stroke), peripheral nervous system (pain, loss of smell and taste) and enteric nervous …