… freezing of gait. DeFOG is a smartphone-based wearable system that delivers personalized cueing to treat freezing of gait. In this study, we will systematically evaluated its potential when used at home and … that continued use of the DeFOG intelligent cueing wearable system over a one month period will reduce freezing of gait …

… imaging scans, a tool for assessing dopamine transporter system dysfunction and thereby Parkinson’s pathology, … alpha-synuclein, such as Dementia with Lewy Bodies (DLB) or Multiple System Atrophy (MSA). The test, on its own, cannot differentiate …

… will utilize a novel programmable pump and catheter system that can improve control of drug dosing and delivery. … disease. Project Description: A novel pump and catheter system for direct infusion to the brain, currently under … in pre-clinical models. The developed pump and catheter system will be surgically inserted into the brain of the …

… on whether placebo treatments actually affect the brain systems disrupted in PD. Understanding placebo effects on … to study placebo effects on the functions of two brain systems related to function and quality of life in Parkinson’s patients, the motor system and the dopamine system. fMRI can measure the …

… accumulation has been reported in the neurons of the GI system, as well as morphology- and activity-based changes of the enteric nervous system (ENS), microbial dysbiosis, and increased gut …

… postural instability and gait disorders. The cholinergic system, a collection of nerve cells that communicate via the … goal is to gain a better understanding of the cholinergic system in GBA-PD and the related clinical symptoms, using … distinct pattern, with more degeneration of the cholinergic system related to the severity of their symptoms, in …