… an internal control and the adaptability of this model for multiple species. Disadvantage: Use of supraphysiological … to area of injection while pathology in PD often occurs in multiple brain regions and peripheral tissues Virus can … lesion with a protracted time course Pathology in multiple brain regions relevant for PD Good for studies …

… Dr. Wu focuses on studying how components of the immune system assemble and communicate. Dr. Wu's laboratory focuses … development for diseases that involve the immune system, including cardiovascular, neurodegenerative and …

… from a prior grant: Analysis of the Enteric Nervous System Using Routine Colonic Biopsies: A Biomarker of … funded by MJFF, we have shown that the enteric nervous system was readily analyzed using routine colonic biopsies … larger scale surveys; second, to study the enteric nervous system (ENS) using colonic biopsies in patients with a …

… neurons in the brain. We propose that the immune system plays a key role in the death of dopaminergic neurons … PD via a mechanism called autoimmunity, when the immune system starts to attack our own cells. The lysosome, a small … and autoimmunity will allow us to target the immune system for the development of novel therapeutic approaches. …

… on antibody targeting of endogenous BBB nutrient transport systems was shown to permit transport of drug cargo from the … of antibodies that can be thought of as in vitro immune systems. Relevance to Diagnosis/Treatment of Parkinson’s … and in contrast to current antibody-based delivery systems, these antibodies will have improved levels of …

… shed new light on the interplay of genetics and the immune system in Parkinson’s disease. In the study, gut infections … that in mice with these genetic mutations, the immune system overreacts with an auto-immune response, resulting in the immune system attacking brain cells. The authors also note the …