… Degenerative disease of the central nervous system, such as Alzheimer’s and Parkinson’s disease, are … proteins through an active cellular garbage collection system called the proteasome. In pathological situations … studies have increasingly suggested that this scavenging system is impaired and can lead to an accumulation of …

… The complement system is composed of a series of proteins which react with … removal of microorganisms and tissue debris by the immune system, but excessive activation of this system can result in cellular injury; inappropriate …

… this problem worse by blocking the cell’s normal recycling systems (lysosomes and autophagy). My recent work has … which naturally acts as a “brake” on these recycling systems and is especially active in neurons. By studying … partners that allow Rubicon to block these recycling systems. These studies will help explain how Rubicon …

… of PD-typical changes (Lewy bodies) in the central nervous system: brainstem areas known to regulate REM sleep are … areas that are closely interconnected with the nervous system of the stomach that is responsible for gastric … LB pathology has also been described in this nervous system of the stomach of PD patients and it is now …

… dysfunction of the locus coeruleus (LC)- noradrenaline (NE) system in the brain not only contributes to alterations in … dopaminergic neurons. While currently the dopamine system remains to be the main therapeutic target, correcting the dysfunctional LC-NE system in PD would improve the efficacy of the current …

… expression the helper dependent version of the adenoviral system will be used. Since the gene delivery system derived from the canine adenovirus 2 has a strong … efficiently than human adenovirus, we will use the canine system. Beside the normal LRRK2 protein, a mutated variant …