-
Using Machine Learning on Longitudinal Data from Multiple Cohorts to Determine Biological Subtypes and Prediction Scores for Parkinson’s Disease
-
Clinical Evaluation of LRRK2 Inhibitors on Inflammatory Responses in Crohn's and Parkinson's Diseases
… LRRK2 in the Immune System …
-
Translation of the Neuroprotective Immune Modulator LBT-3627 into First-In-Human Studies
… well as people with PD who exhibit a dysfunctional immune system. Participants will be treated with a single dose of … Adaptive immune system … peripheral immune system …
-
Feeding with Clostridium Leptum for Restoring the Integrity of the Striatal Dopaminergic System in a Pre-clinical Model of Parkinson’s Disease
… and reduce toxicant-mediated toxicity of striatal dopamine system. Project Description: In this study, we … neuroprotective effect on MPTP-induced striatal dopamine system toxicity by measuring the concentrations of dopamine …
-
Effects of noradrenergic or serotoninergic system lesions combined with NS lesions on rodent models of 'non-motor'-like symptoms
… little attention. Damage to all these neuronal systems would contribute to comorbid anxiety, depression and …
-
Evaluation of the Inflammation-blocking Drug Tolebrutinib as a Novel Disease-modifying Therapeutic for Parkinson's Disease
… the effectiveness of Tolebrutinib in cell culture and in multiple preclinical animal models of PD. We will determine … shown to be safe and well-tolerated in clinical trials for multiple sclerosis. If this project is successful, … peripheral immune system …