… original grant was to utilize pre-clinical and human model systems to better understand LRRK biology. The original aims … LRRK2 KO model with respect to the dopaminergic system and 3) create human lines containing PD associated … the role of autophagy in basic LRRK2 biology, in the immune system, and in mitochondrial quality control. Importance of …

… to alter a particular location in the genome. The CRISPR system penetrates the cells through a safe delivery system and will only change the expression of the SNCA gene … study will optimize delivery and the design of the CRISPR system in pre-clinical models of tParkinson’s disease and …

… all cell types in our body. We have established a culture system to induce human ES cells to give rise to precursors … of brain and spinal cord cells. We will create a culture system that allows the neural precursors to generate … dopamine neurons. This way, we will optimize the culture system to generate maximal number of transplantable dopamine …

… of Nebraska Medical Center that aims at using the immune system to fight Parkinson’s disease offers what one … how a vaccine could be used to trigger the immune system to fight Parkinson’s. The latest version of the … and balance. The loss triggers a response in the immune system that destroys even more of the dopamine-producing …

… Study Rationale:                              Multiple lines of evidence suggest that alpha-synuclein …

… to treat Parkinson’s. Dr. Brundin also has coordinated multiple international research programs. He is heavily …