… affected by neurologic injury through a combination of systems neuroscience, translational engineering, and deep … cord injury to regain hand grasp using a neuroprosthetic system in the home environment. He also co-led the …

… Parkinson's disease (PD), are a family of central nervous system (CNS) degenerative disorders characterized by … which includes TLR2, play a critical role in the immune system's response to foreign pathogens that can trigger … suggesting alpha-synuclein aggregates activate the immune system to increase adverse inflammation signaling. Thus, …

… Hypothesis: We will evaluate the therapeutic effect of systemic XPro1595 in a pre-clinical model using motor and … Study Design: We will assess the extent to which systemic XPro1595 administration reduces neuroinflammation … of Parkinson's Disease: Successful results with systemic XPro1595 on inflammatory markers and non-motor …

… and Metabolomics Study Rationale:  The endolysosomal system in living cells is comprised of small, specialized … and remove molecular waste. Impaired function of this system leads to a build-up of toxic proteins and … that improve the impaired function of the endolysosomal system to benefit people with PD. Identifying biomarkers (or …

… to neurobiology, McKay showed that the nervous system was composed of many molecularly distinct neuronal … extraordinary biochemical complexity of the central nervous system (CNS). His recent work has focused on the stem cells … of stem cells in the developing and adult nervous system. They challenge the textbook view that the …

… this new definition, the paper’s authors propose a staging system — the neuronal alpha-synuclein disease integrated staging system (NSD-ISS) — that promises to be a research … achieve a paradigm shift in how PD is defined and staged, multiple diverse stakeholders need to come together and …