… of transmembrane receptors, the role of the ubiquitin system in protein regulation, and in development of … to manipulate specific components of the ubiquitin system as a basis for therapeutics. Dr. Weissman has been …

… abnormal cellular proteins via the ubiquitin-proteasome system. It has been hypothesized that parkin is important in … is to be tested, it is crucial that the experimental system allows for the examination of what happens when …

… role in developing and managing MJFF’s grant management system (the Grant Portal) and integrating it with other … The Associate Director, Research Operations, sits on the Systems, Analytics, and Processes (SAP) unit of the Research … throughout entire funding opportunity process to ensure the system is meeting needs for triage reviews, full proposal …

… the MPTP-induced degenerative process in the nigrostriatal system will be assessed. Relevance to Diagnosis/Treatment of … expression of alpha synuclein in the nigrostriatal system. If successful, this can be applied to other regions … delivery of microRNA’s 7 and 153 protect the nigrostriatal system from MPTP toxicity.   …

… the MPTP-induced degenerative process in the nigrostriatal system will be assessed. Relevance to Diagnosis/Treatment of … expression of alpha-synuclein in the nigrostriatal system. If successful, this can be applied to other regions … delivery of microRNA’s 7 and 153 protect the nigrostriatal system from MPTP toxicity.   …

… in Parkinson’s disease (PD). Each of these signaling systems contributes to the brain inflammation and breakdown … Kv1.3. We further hypothesize that an imbalance in this system will lead over time to PD pathology.  Study Design:  … manipulation of the Kv1.3 and inflammasome signaling systems have on measures of PD progression to obtain a …