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LRRK2 Role on Auto-antibody Production by Human B Cells
… B lymphocytes are cells of the immune system that have a dual function: they produce antibodies to … communication between B cells and other cells of the immune system. We will also try to understand how LRRK2-G2019S … and communication capacity with other cells of the immune system are severely deregulated. Such deregulation, in …
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Patient, Research and Industry Leaders Propose Biological Definition and First Biological Staging for Parkinson’s Disease
January 23, 2024
… this new definition, the paper’s authors propose a staging system — the neuronal alpha-synuclein disease integrated staging system (NSD-ISS) — that promises to be a research … achieve a paradigm shift in how PD is defined and staged, multiple diverse stakeholders need to come together and …
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Precision Medicine Drives Momentum at the PPMI Annual Meeting
May 29, 2026
… researcher Kalpana Merchant, PhD, explained, “We’re taking multiple shots on goal.” Drs. Kalpana Merchant, Brit … to looking at markers that flag changes in the immune system and other cell activities. Biomarkers also may help … projects starting in the coming months. Refined Staging Systems Across presentations, researchers offered insight …
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Assessing TRPML1 Agonists in GBA Parkinson’s Disease
… of waste materials and cause a variety of diseases. Multiple forms of Parkinson’s disease (PD) are linked to …
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Evaluating the Efficacy of a mGluR5 Modulator in Preclinical Models of Parkinson’s Disease
… in the prevention and reversal of disease phenotypes in multiple preclinical mouse models of PD, testing both …
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Mechanisms Overwhelming Protein and Organelle Quality Control in Parkinson’s Disease
… disease (PD) and can damage cells, including neurons. Multiple mechanisms of aggregate toxicity have been …