-
Associate Director, Research Operations
… role in developing and managing MJFF’s grant management system (the Grant Portal) and integrating it with other … The Associate Director, Research Operations, sits on the Systems, Analytics, and Processes (SAP) unit of the Research … throughout entire funding opportunity process to ensure the system is meeting needs for triage reviews, full proposal …
-
Gene delivery of miRNAs to reduce alpha synuclein: a new therapy for PD
… the MPTP-induced degenerative process in the nigrostriatal system will be assessed. Relevance to Diagnosis/Treatment of … expression of alpha synuclein in the nigrostriatal system. If successful, this can be applied to other regions … delivery of microRNA’s 7 and 153 protect the nigrostriatal system from MPTP toxicity. …
-
Gene Delivery of MiRNAs to Reduce Alpha-synuclein: A New Therapy for PD
… the MPTP-induced degenerative process in the nigrostriatal system will be assessed. Relevance to Diagnosis/Treatment of … expression of alpha-synuclein in the nigrostriatal system. If successful, this can be applied to other regions … delivery of microRNA’s 7 and 153 protect the nigrostriatal system from MPTP toxicity. …
-
Examining the Action of Potassium Channels and the Inflammasome in a Signaling Axis That Can Serve as a Pharmacological Target Against Parkinson’s Disease
… in Parkinson’s disease (PD). Each of these signaling systems contributes to the brain inflammation and breakdown … Kv1.3. We further hypothesize that an imbalance in this system will lead over time to PD pathology. Study Design: … manipulation of the Kv1.3 and inflammasome signaling systems have on measures of PD progression to obtain a …
-
Developing Small Molecules to Enhance Autophagy and Clear Alpha-synuclein Aggregates as a Treatment for Parkinson’s Disease
… will reduce alpha-synuclein accumulation in the nervous system and improve motor and non-motor symptoms, effectively … produce the human alpha-synuclein protein in their nervous system; these animals exhibit motor and non-motor symptoms … by measuring the levels of alpha-synuclein in the nervous system. Impact on Diagnosis/Treatment of Parkinson’s …
-
FDA Approves Parkinson's Psychosis Drug
April 29, 2016
… medications worked on both the dopamine and serotonin systems. Parkinson’s medications for motor symptoms also work on the dopamine system, and taking antipsychotics blocked the effect of … for Parkinson's psychosis, works only on the serotonin system. Clinical trials showed the drug eased psychosis …