… and has proven to be an excellent in vivo animal model system for developmental and degenerative processes directly … of alpha-synuclein in the Drosophila central nervous system causes neurodegeneration and progressive … Parkinson's disease that cannot be matched by any mammalian system. As new genes are identified and characterized, we …

… processes and bodily (e.g., immune and gastrointestinal system) functions. We also hypothesize that these biomarkers … whether, and how, these variants interact with the immune system, the lysosomal system (responsible for the “garbage disposal” in our …

… to the accumulation of the toxic protein alpha-synuclein. Systems within neurons able to clear alpha-synuclein become … developing therapies aimed at improving the ability of such systems to reduce alpha-synuclein. Trehalose is a safely …

… yet unknown viruses, are able to reach the central nervous system and remain latent by hiding in neurons, thereby escaping detection from the immune system. Recurrent reactivation during aging triggers an …

… disease (PD). We propose to develop a gene therapy system that will allow us to reduce the activity of the … therapy and peripheral organs and assess how the immune system responds to the treatment. Impact on …

… of neural networks to molecular and biomolecular systems. He has made over 200 presentations at regional, … in computer modeling techniques of atomic and molecular systems for the elucidation of their chemical and physical …